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Artigo 19 - Progesterone and Estrogen

Summary:

Neurofi bromatosis type 1 (NF1) or von Recklinghausen disease is a genetic disorder affecting the growth of cells in nervous system. One of the most remarkable characteristics of this disease is the development of benign tumors of the nervous system (neurofibromas).

Progesterone and Estrogen Receptors in Neurofi bromas of Patients with NF1

Summary:

Neurofi bromatosis type 1 (NF1) or von Recklinghausen disease is a genetic disorder affecting the growth of cells in nervous system. One of the most remarkable characteristics of this disease is the development of benign tumors of the nervous system (neurofibromas).

The purpose of this study was to test tissue samples taken from neurofi bromas and plexiform neurofi bromas of NF1 patients for the presence of estrogen and progesterone receptors. We used previously collected samples from patients registered in the database of the Centro Nacional de Neurofi bromatose (CNNF-Brazil). Samples from twenty-fi ve patients in the database presenting plexiform neurofi bromas (N1 group) and 25 samples from the same database from patients presenting neurofibromas (N2 group) were tested.

We observed positive staining for progesterone receptors in 13 of the neurofi broma samples and 19 of the plexiform neurofi broma samples. Among the neurofi broma samples, we observed one sample with positive estrogen receptor staining, but none of the plexiform neurofi broma samples showed positive staining. We suggest further studies to investigate in greater depth possible hormonal infl uences on the development and growth of neurofi bromas and plexiform neurofi bromas in NF1.

Leia o Artigo completo através do link a seguir (necessário o programa Acrobat Reader – documento em PDF):

http://cnnf.org.br/portalnf/images/artigos/f_cmpath-1-geller-et-al_1517.pdf

 
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